Search results for "Familial clustering"
showing 4 items of 4 documents
Autoimmune polyglandular diseases.
2019
Autoimmune polyglandular diseases (APD) are defined as the presence of two autoimmune -induced endocrine failures. With respect to the significant morbidity and potential mortality of APD, the diagnostic objective is to detect APD at an early stage, with the advantage of less frequent complications, effective therapy and better prognosis. This requires that patients at risk be regularly screened for subclinical endocrinopathies prior to clinical manifestation. Regarding the time interval between manifestation of first and further endocrinopathies, regular and long-term follow-up is warranted. Quality of life and psychosocial status are poor in APD patients and involved relatives. Familial c…
C4BQ0: a genetic marker of familial HCV-related liver cirrhosis
2004
Source Department of Medicine and Pneumology, V Cervello Hospital, Via Trabucco 180, 90146 Palermo, Italy. lindpas@yahoo.it Abstract BACKGROUND AND METHODS: Host may have a role in the evolution of chronic HCV liver disease. We performed two cross-sectional prospective studies to evaluate the prevalence of cirrhosis in first degree relatives of patients with cirrhosis and the role of two major histocompatibility complex class III alleles BF and C4 versus HCV as risk factors for familial clustering. FINDINGS: Ninety-three (18.6%) of 500 patients with cirrhosis had at least one cirrhotic first degree relative as compared to 13 (2.6%) of 500 controls, (OR 7.38; CI 4.21-12.9). C4BQ0 was signifi…
Das polyglanduläre Autoimmunsyndrom – Lebensqualität und familiäre Beteiligung
2014
Hintergrund und Fragestellung: Fur Patienten mit einem Polyglandularem Autoimmunsyndrom (PGA) und ihre Angehorigen liegen keine Daten zur familiaren Beteiligung und zur Lebensqualitat vor. Daher erfolgte eine Erhebung in einer reprasentativen Gruppe. Patienten und Methoden: Im Rahmen einer prospektiv angelegten und kontrollierten Studie wurden klinische und serologische Untersuchungen an 75 konsekutiv aufgenommenen Patienten mit PGA (mittleres Alter 47,5 ± 15,3 Jahre; 65,3 % Frauen) mit 108 Angehorigen (mittleres Alter 33,13 Jahre ± 20,08 Jahre; 65,7% Frauen) durchgefuhrt. Drei validierte Messinstrumente (Short Form 36 [SF-36], Hospital Anxiety and Depression Scale [HADS] und Giesener Be…